SafeBit 

SafeBit features military strength on-the-fly AES encryption, by creating virtual disk drives, where you can hide files and folders, keep them encrypted all them time, but still work with these files just like you work with normal files.
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TurboCrypt: Disk Encryption Software 

512 Bit, Transparent, On-The Fly Disk Encryption; Strong Security Made Easy. Enter your password once to unlock the encrypted drive, and then access all encrypted files stored on that drive. Create encrypted Volumes up to 2,000 Gigs in size.
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StrongDisk Pro 

StrongDisk Pro is the most proven and reliable on-the-fly encryption software exists on the market. It makes a plain hard disk into a data strongbox that can be accessed by its owner only.
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DriveCryptPlusPack 

DCPP allows you to secure your disk(s) (including removable media) with a powerful and proven encryption algorithm (AES-256) at the sector level, ensuring that only authorized users may access it.
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